Abstract
Chromophobe renal cell carcinoma (RCC) is a rare type of kidney neoplasm that is diagnosed in the 6th decade of life with similar incidence in male and female. We reported a case of 73-year-old man with a chief complaint of nocturia, frequency, dribbling and urinary retention with renal mass in ultrasound examination. Histologic examination and immunohistochemistry study revealed the diagnosis of chromophobe RCC which initially was mistaken for oncocytoma in frozen section diagnosis. The pathologist should be aware of this malignant entity and be cautious in diagnosing oncocytoma in frozen section and routine H & E staining.
Highlights
Chromophobe renal cell carcinoma (RCC) is a rare neoplasm of the kidney that represents about 5% of RCCs
The purpose of the study was to report a case with chromophobe RCC that had a challenge in frozen section diagnosis
The pathologists must be kept in mind that, encountering a renal mass with oncocytic features or eosinophilic cytoplasms in frozen section is not equal to merely oncocytoma
Summary
Chromophobe renal cell carcinoma (RCC) is a rare neoplasm of the kidney that represents about 5% of RCCs. The 5-and 10-year survival rates of this cancer are reported 100 and 90%, respectively [2]. This neoplasm is more common in the 6th decade of life [3]. The purpose of the study was to report a case with chromophobe RCC that had a challenge in frozen section diagnosis. The pathologists must be kept in mind that, encountering a renal mass with oncocytic features or eosinophilic cytoplasms in frozen section is not equal to merely oncocytoma. An important differential diagnosis of chromophobe RCC needs to be suggested to the surgeon and definite diagnosis should be postponed to permanent sections and immunohistochemistry (IHC) study
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