Abstract
Five new chromone-derived polyketides phaseolorins A-F (1–5), together with nine known compounds, were isolated from the deep-sea derived fungus Diaporthe phaseolorum FS431. The structures of new compounds were determined by analysis of their NMR and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic data. The absolute configurations were confirmed by chemical transformations, extensively experimental electron capture detection (ECD) calculations, or X-ray crystallography. Among them, compound 2 represented the first example for a new family of chromone derivative possessing an unprecedented recombined five-member γ-lactone ring. Moreover, the new compounds (1–5) were evaluated for in vitro cytotoxic activities against a panel of human cancer cell lines.
Highlights
Marine-derived fungi are emerging as a promising source for discovering novel natural products with significant biological and pharmacological properties
Previous studies towards the fungi of the genus Diaporthe have revealed that these fungi are capable of producing structurally fascinating and architecturally diverse natural products, such as polyketides, highly substituted benzophenone, pyran-2-one, terpenoid, and diapolic acid [3,4,5,6,7], which usually showed potent cGMP-dependent protein kinase inhibitory and antiparasitic [4], antibacterial [8,9], antimalarial [10], and cytotoxic activities [11,12]
The IR spectrum displayed the classical absorption bands at 3362, 1771, and 1614 cm−1, which were characteristic for the hydroxy, γ-lactone carbonyl, and conjugated ketone
Summary
Marine-derived fungi are emerging as a promising source for discovering novel natural products with significant biological and pharmacological properties. Deep-sea fungi have attracted even more attention in recent years because they are naturally forced to metabolize more potent bioactive compounds to acclimatize the extreme and variable environments of the deep sea, which has resulted in the generation of numerous chemically diverse and structurally unique secondary metabolites. Deep-sea fungi have been proverbially respected to be one of the most potential resources for the discovery of biologically meaningful natural products [1,2]. G (6) [13], 4-hydroxyphenthyl methyl known derivatives identified as phomoxanthone.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
