Abstract
The fungal strain YPGA3 was isolated from the sediments of the Yap Trench and identified as Penicillium thomii. Eight new chromone derivatives, named penithochromones M−T (1–8), along with two known analogues, 9 and 10, were isolated from the strain. The structures were established by detailed analyses of the spectroscopic data. The absolute configuration of the only chiral center in compound 1 was tentatively determined by comparing the experimental and the calculated specific rotations. Compounds 7 and 8 represent the first examples of chromone derivatives featuring a 5,7-dioxygenated chromone moiety with a 9-carbon side chain. Bioassay study revealed that compounds 6–10 exhibited remarkable inhibition against α-glucosidase with IC50 values ranging from 268 to 1017 μM, which are more active than the positive control acarbose (1.3 mmol).
Highlights
Chromone is a group of oxygen-bearing heterocyclic molecules featured by a benzoannelated γ-pyrone ring
Natural products containing a chromone moiety are widespread in nature and display various biological activities, such as antioxidant, antiviral, and anti-inflammatory activities [1]
The results showed that compounds 9 and 10 displayed significant inhibitory effects with IC50 values of 688 and 268 μM respectively, being much more effective than the positive control acarbose
Summary
Chromone is a group of oxygen-bearing heterocyclic molecules featured by a benzoannelated γ-pyrone ring. The chemical study of marine fungi has led to the discovery of numerous new or bioactive compounds, contributing greatly to natural products chemistry [2,3,4,5,6]. Among these metabolites, some chromone derivatives exhibit significant activity, the following are some examples.
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