Abstract
AbstractChromobacterium violaceum is an opportunistic human pathogen causing a range of gastric infections and occasionally septicemia. This Gram-negative bacillus is a common inhabitant of soil and water in tropical and subtropical areas of the world. Infection occurs after contamination of damaged skin exposed to soil or environmental water. Alternatively, systemic infection can follow the aspiration or ingestion of contaminated water. The major features of infections by C. violaceum are, in generally, rapid clinical course, multiple visceral abscesses, and high mortality. Genomic data on the type strain ATCC 12472 has provided a comprehensive basis for detailed studies of pathogenicity, virulence and drug resistance genes. In this study, the susceptibility of this organism was tested on a variety of drugs at different concentrations, in solid and liquid media. C. violaceum shown to be resistance to ampicilin, penicillin, rifampicin, erythromycin, vancomycin and also to ethidium bromide. The bacteria was susceptible to gentamicin, tetracycline, chloramphenicol, cotrimoxazole, kanamycin, streptomycin and nalidixic acid, at the tested concentrations.
Highlights
Chromobacterium violaceum is a common inhabitant of soil and water in tropical and subtropical regions
They belong to three different families of transport proteins: the major facilitator superfamily (MFS) (Saidijam et al 2006; Vardy et al 2004), the resistance nodulation division (RND) family (Gotoh et al 1999; Piddock, 2006; Saier et al 1994), and the small multidrug resistance (SMR) family of small translocases (Jack et al 2000; Paulsen et al 1996; Tate, 2006)
We provided experimental data of drug resistance of
Summary
Chromobacterium violaceum is a common inhabitant of soil and water in tropical and subtropical regions. The first case in humans was reported in Malaysia in 1927, and the medical literature contains reports of approximately 150 human cases since (Midani & Rathore, 1998; Ray et al 2004; Teoh et al 2006) This bacteria is able effective survival mechanism (Brito et al 2004; Duran & Menck, 2001). A variety of MDR efflux systems are widely distributed among prokaryotic microorganisms, including pathogenic bacteria (Aeschlimann, 2003; Lewis, 1994; Lewis et al 1994; Marquez, 2005) They belong to three different families of transport proteins: the major facilitator superfamily (MFS) (Saidijam et al 2006; Vardy et al 2004), the resistance nodulation division (RND) family (Gotoh et al 1999; Piddock, 2006; Saier et al 1994), and the small multidrug resistance (SMR) family of small translocases (Jack et al 2000; Paulsen et al 1996; Tate, 2006). Ethidium bromide was tested, in order to confirm the resistance to this toxic compound, as indicated by the genome data
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