Chromium-Containing Traditional Chinese Medicine, Tianmai Xiaoke Tablet, for Newly Diagnosed Type 2 Diabetes Mellitus: A Meta-Analysis and Systematic Review of Randomized Clinical Trials.

Yuming Gu,Lejun Cao,Xueyang Wang,Xiuzhi Liu,Bo Feng,Zhe Wang,Zhengxin Li,Yunsheng Xu,Xuemin Xu

doi:10.1155/2018/3708637

Abstract

Objective Chromium-containing traditional Chinese medicine Tianmai Xiaoke tablet (TMXKT) is approved for treating newly diagnosed type 2 diabetes mellitus (T2DM) in China. This review aimed to compile the evidence from randomized clinical trials (RCTs) and quantify the effects of TMXKT on newly diagnosed T2DM. MethodsSeven online databases were investigated up to March 20, 2017. The meta-analysis included RCTs investigating the treatment of newly diagnosed T2DM, in which TMXKT combined with conventional therapy was compared with placebo or conventional therapy. The risk of bias was evaluated using the Cochrane Collaboration tool. The estimated mean difference (MD) and the standardized mean difference were within 95% confidence intervals (CI) with respect to the interstudy heterogeneity. The outcomes were measured using fasting blood glucose (FBG), 2-h postprandial blood glucose (2hPG), glycosylated hemoglobin A1c (HbA1c), and body mass index (BMI) levels. ResultsTMXKT combined with conventional therapy lowered FBG level (MD = −0.68, 95% CI −0.90 to −0.45, P < 0.00001), 2hPG (MD = −1.33, 95% CI −1.86 to −0.79, P < 0.00001), HbA1c (MD = −0.46, 95% CI −0.57 to −0.36, P < 0.00001), and BMI (MD = −0.77, 95% CI −1.12 to −0.41, P < 0.00001). ConclusionsTMXKT combined with conventional therapy is beneficial for patients with newly diagnosed T2DM. However, the effectiveness and safety of TMXKT are uncertain because of the limited number of trials and low methodological quality. Therefore, practitioners should be cautious when applying TMXKT in daily practice. Also, well-designed clinical trials are needed in the future.

Highlights

Diabetes mellitus (DM) has reached epidemic proportions globally
DM is characterized by hyperglycemia with disturbances in carbohydrate, fat, and lipid metabolism resulting from defects in insulin secretion, insulin action, or both [1]
mean difference (MD) for Tianmai Xiaoke tablet (TMXKT) combined with conventional therapy versus conventional therapy alone was −0.68 over the treatment period

Summary

Introduction

Diabetes mellitus (DM) has reached epidemic proportions globally. DM is characterized by hyperglycemia with disturbances in carbohydrate, fat, and lipid metabolism resulting from defects in insulin secretion, insulin action, or both [1]. The most recent data indicates 37.1 million patients with type 2 diabetes mellitus (T2DM) worldwide, of which 11.6% are from China. DM can lead to serious complications, including cardiovascular and kidney diseases, blindness, and amputations. It is a major cause of mortality. It is imperative that more attention is paid to the prevention and treatment of T2DM, especially newly diagnosed T2DM

Methods

Results

Conclusion