Abstract
The effects of chromium on chick embryos were analyzed in the present study. Chromium trioxide was dissolved in saline and injected into embryonating chicken eggs at doses ranging from 0.002 to 0.05 mg per egg. The injections were made into the air sacs of eggs at Days 0, 1, 2, 3, and 4 of incubation. Control eggs were injected with an equivalent volume of saline (0.1 ml per egg). In all, 840 chicken eggs were used for this study. All the embryos were examined at Day 8. The following malformations were observed: short and twisted limbs, microphthalmia, exencephaly, short and twisted neck, everted viscera, edema, and reduced body size. Most of the embryos showed unilateral and bilateral limb defects. The results of the present study indicate that chromium trioxide has tendency to cause malformations in the chick embryos tested.
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