Abstract
Trivalent chromium (Cr3+) supplementation is widely used by the general public to improve normal protein, fat and carbohydrate metabolism. The present study examined the effect of oral supplementation with chromium nicotinate (CDN), chromium dinicocysteinate (CDNC), or L‐cysteine (LC) on fasting levels of blood glucose, glycosylated hemoglobin (HbA1), C‐reactive protein (CRP), monocyte chemoattractant protein‐1 (MCP‐1), adiponectin, vitamin C, and lipid peroxidation (LP) in Zucker diabetic fatty (ZDF) rats. Control buffer, CDN or CDNC (400 μg Cr/kg BW), and LC (0.93 mg/kg BW) was administered by gavage daily for 8 wks. Blood was collected by heart puncture using light anesthesia. With increasing age, ZDF rats had elevated blood levels of glucose, HbA1, CRP, MCP‐1 and decreased levels of adiponectin and vitamin C. Compared to control, CDNC supplementation showed a significant decrease in glucose, HbA1, CRP, MCP‐1 and LP. Compared to controls, only CDNC supplementation caused a significant increase in levels of adiponectin and vitamin C. There was no change in blood markers of liver and kidney function tests in CDNC supplemented group. This study demonstrates that chromium dinicocysteinate supplementation can lower the risk of glycemia and vascular inflammation in ZDF rats. Research was supported by InterHealth, Benicia, CA.
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