Abstract
An efficient, chromium-catalyzed highly enantioselective preparation of protected 1, 3-diols has been achieved. In the presence of a chiral chromium catalyst using the carbazole-based bisoxazoline as the chiral ligand, a variety of optically pure 1,3-diols were synthesized in 34%-87% yields with up to 98% ee. The benzyl as well as silyl ethers were suitable substitutions for the hydroxyl group. Meanwhile, aromatic, aliphatic and α, β-unsaturated aldehydes are well tolerated under the mild reaction conditions.
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