Abstract
Abstract A chromatographic-UV spectrophotometric method for the determination of menadione in tablets, utilizing the conversion of menadione to menadione sodium bisulfite, has been developed. The sample is treated with sodium bisulfite and the resultant menadione sodium bisulfite is analyzed by the method of Johnson. A column prewash with CHCl3 removes impurities or degradation products present in the original menadione sample. The menadione is then eluted with an ammonia-saturated CHCl3 solution. The method worked equally well on coated and uncoated tablets and it has the advantage of determining only the amount of menadione and not degradation products present in the sample.
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