Abstract
Four highly toxic fractions (I-B-2, I-C, III-A and III-B) were obtained from the venom of the Indian krait ( Bungarus caeruleus) by CM-cellulose column chromatography, followed by various steps of gel filtration on Sephadex G-50 and rechromatography on CM-Sephadex C-25. Among them, fractions III-A and III-B proved to be homogeneous on disc-electrophoresis. Based on the ld 50 in mice, time to death at higher doses, and especially the effect on acetylcholine response of the rat denervated diaphragm as well as the chick biventer cervicis muscle, it is concluded that fractions I-B-2 and I-C belong to postsynaptically acting neurotoxins, similar to α-bungarotoxin, whereas fractions III-A and III-B belong to presynaptically acting neurotoxins, similar to β-bungarotoxin.
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