Abstract
A procedure was developed for preparing high radiochemical purity 99mTc-valsartan with yield of 98%. The complex was prepared by mixing of valsartan with SnCl2.2H2O solution and the pH of the mixture was adjusted to 8 then mixed with a freshly eluted 99mTc O4- (~400 MBq), shacked at room temperature for 30 min. The radiochemical yield and purity of the labeled product were determined individually by HPLC, paper chromatography and paper electrophoresis. Biodistribution studies were carried out in normal Albino Swiss mice at different time intervals after administration of 99mTc-valsartan. The labeled compound cleared from the systematic circulation within 2 h afteradministration, and the majority of organs showed significant decrease in the uptake of 99mTc-valsartan. The heart uptake of 99mTc-valsartan was sufficiently high for using this agent as myocardial imaging agent.
Highlights
Valsartan is indicated for the treatment of hypertension, to lower blood pressure
Radiochemical yield of 99mTc-valsartan was checked by paper chromatographic method in which, the reaction product was spotted on ascending paper chromatography strips (10×1.5 cm)
Free 99mTc O4-moved with the solvent front (Rf=1), while 99mTc-valsartan and reduced hydrolyzed technetium remained at the point of spotting
Summary
Valsartan is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trials in hypertensive patients demonstrating risk reduction with Diovan. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Valsartan is potent Angiotensin II receptor blocker. It is mainly used as antihypertensive drug [3,4]
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