Abstract
IntroductionGastrointestinal diseases are major reasons for morbidity in Mali. As Helicobacter pylori is known to play a major role in gastritis and gastric ulcer we wanted to find a simple method for detection.MethodsTwenty-nine volunteers with confirmed gastric ulcer by gastroscopy and 59 randomly selected volunteers were diagnosed by using the rapid serological test Clearview® H. Pylori. The ImmunoCard STAT!® HpSA®test was applied on stool from 65 volunteers seeking help for gastrointestinal related ailments.ResultsA Helicobacter pylori prevalence of 21% was found among the individuals with confirmed gastric ulcer, 44% among the randomly selected volunteers and 14% in individuals with gastrointestinal related ailments.ConclusionAccording to what is already known about the aetiology of gastric ailments and the prevalence of Helicobacter pylori in neighboring countries, the infection rates in our study appear strikingly low. This might indicate that Clearview® H. Pylori and ImmunoCard STAT!® HpSA® have low sensitivities in the populations studied. Strain variability of H. Pylori may be an explanation. The tests need to be properly evaluated in Mali before they can be relied upon as diagnostic tools.
Highlights
Gastrointestinal diseases are major reasons for morbidity in Mali
It is important to increase the knowledge behind the aetiology of gastritis, gastric ulcer and GI-related problems in Mali for future research on Malian traditional medicines used for these ailments, and in order to give patients the correct treatment.The presence of Helicobacter pylori in the population is one important factor needing assessment, as H
H. pylori antibodies were detected in 21% of the 29 volunteers diagnosed with gastric ulcer by gastroscopy (Table 1)
Summary
Gastrointestinal diseases are major reasons for morbidity in Mali. As Helicobacter pylori is known to play a major role in gastritis and gastric ulcer we wanted to find a simple method for detection. Conclusion: According to what is already known about the aetiology of gastric ailments and the prevalence of Helicobacter pylori in neighboring countries, the infection rates in our study appear strikingly low. It is important to increase the knowledge behind the aetiology of gastritis, gastric ulcer and GI-related problems in Mali for future research on Malian traditional medicines used for these ailments, and in order to give patients the correct treatment.The presence of Helicobacter pylori in the population is one important factor needing assessment, as H. In Senegal a prevalence of 100% was found in patients with ulcers or gastritis by urea breath test and histological findings [12]
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