Abstract
A study of the chromatographic behavior of some cough syrup ingredients has led to the optimum chromatographic separation of four ingredients (doxylamine succinate, phenylpropanolamine hydrochloride, chlorpheniramine maleate, and dextromethorphan hydrobromide). The paracetamol and guaifenesin were overlapping under all chromatographic conditions. The application of 1% chlorotrimethylsilane in methanol to the column (Partisil 5 CCS/C 8) was found to improve the column efficiency significantly. This separation can be applied for the analysis of cough syrup for these ingredients after a study of the interferences due to normal excipients. 2 2 Excipient: any inert substance used as a diluent or vehicle for a drug.
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