Abstract
Transcriptional regulation plays an important role in development. Originally, studies of transcriptional regulation used specific promoter regions, either in the form of naked DNA or in a nucleosome context. In addition, the chromatin immunoprecipitation (ChIP) technique allowed researchers to establish the relationships of certain regulatory proteins, kinases, histone modifications and so on, with given regions of genomic DNA, thereby providing information in a more relevant chromatin context. More recent studies, however, focus on global changes in particular loci, which include many different genes and regulatory regions. The chicken β-globin locus has been particularly useful, not least because an established cell line system exists that represents the various developmental stages of this region.
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