Abstract
We examined effects of novobiocin alone or in combination with γ-irradiation, on the frequencies of chromatid-type aberrations in a novobiocin-resistant subline of Chinese hamster V79 cells (NOVO r-1). NOVO r-1 cells were significantly resistant to novobiocin, as compared to wild-type V79 (WT) cells, with respect to cell survival and DNA synthesis. Survival responses of WT and NOOV r-1 cells to γ-rays in the range 2–10 Gy differed only slightly and the number of chromatid aberrations produced by irradiation at 1 Gy was fairly comparable in the two cell types. Post-irradiation treatment of cells with novobiocin at concentrations exceeding 200 μg/ml significantly increased the number of chromatid gaps plus breaks in WT cells as compared with NOVO r-1 cells. With 200 μg/ml the increase was 1.2-fold ( t-test, P < 0.05) and with 400 μg/ml, 2.3-fold ( P < 0.01) the number produced in NOVO r-1 cells.
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