Abstract
Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianumNurul Iman Aminudin, Farediah Ahmad, Muhammad Taher, Razauden Mohamed Zulkifli
Highlights
Sponges are the most well-studied animals among the marine invertebrates, from which a vast array of bioactive compounds have been isolated (Hu et al, 2015)
According to the review by Mehbub et al (2014), Indonesia is the highest contributor of new compounds from marine sponges in tropical countries, and new compounds are continuously being found from the Indonesian marine sponges, as exemplified by tetradehydrohalicyclamine B from Acanthostrongylophora ingens (Kato et al, 2019), (+)-jasplakinolide Z6 from Jaspis splendens (Ebada et al, 2019), and nakijiquinone V from Dactylospongia elegans (Balansa et al, 2019)
Marine microorganisms are considered to have a potent capability of producing novel bioactive compounds that were acquired through the evolutionary pressure they suffer under unique physical, chemical, and biological conditions of the marine environment
Summary
Sponges are the most well-studied animals among the marine invertebrates, from which a vast array of bioactive compounds have been isolated (Hu et al, 2015). Sponge-associated fungi are attracting attention as a productive source of new chemical entities (Liu et al, 2018; Pang et al, 2018; Wang et al, 2018). It is assumed that sponge-associated fungi from Xestospongia might have the potential to produce structurally diverse compounds. The first example is the antimicrobial xestodecalactones from Xestospongia-derived Penicillium cf montanense reported by Edrada et al (2002). Another case is a series of antibacterial chromones reported by Lin et al (2003) from Aspergillus versicolor isolated from Xestospongia exigua
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