Abstract
Preliminary clinical trials reported with adrenal medullary transplants into the CSF for irreductible cancer pain were contradictory. The objective of these phase II study is to confirm the faisability and to evaluate the analgesic activity effects of these approach. The prospective study concern 20 allofrafts for 15 irreductible cancer pain, after failure of oral opioids. All the patients were treated by daily intrathecal (I-Th) morphine administration. The mean follow-up is 92 days (15-365). The analgesic effects are interpreted in function of 3 parameters: pain intensity score (from 0 to 10), activity pattern and complementary narcotic intake. The results were excellent (pain score: 0-1, complete interruption of I-Th morphine) in 5 cases; good (pain score <2, diminution of I-Th morphine) in 2 cases; moderate (pain score < 3, stability of I-Th morphine) in 4 cases; and evaluated as failure (pain > 3, increase of I-Th morphine) in 3 cases. Clinical data...
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