Abstract
As Professor of Primary Care in the Nuffield Department of Primary Care Health Sciences at the University of Oxford, UK, and a practising general practitioner in south Wales, Chris Butler has a bird's eye view of the potential impact of primary care research on clinical practice. Unsurprisingly, COVID-19 research is a priority, with Butler co-leading the PRINCIPLE trial to try and identify treatments for the alleviation of COVID-19 symptoms in community settings. “I am hopeful that our innovations in research methods will identify effective early treatment for the disease”, he says. Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trialOur findings do not justify the routine use of azithromycin for reducing time to recovery or risk of hospitalisation for people with suspected COVID-19 in the community. These findings have important antibiotic stewardship implications during this pandemic, as inappropriate use of antibiotics leads to increased antimicrobial resistance, and there is evidence that azithromycin use increased during the pandemic in the UK. Full-Text PDF Open Access
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