Choroidal Vascularity Map in Unilateral Central Serous Chorioretinopathy: A Comparison with Fellow and Healthy Eyes.

Kiran Kumar Vupparaboina,Claudio Iovino,Mohammed Abdul Rasheed,Gideon Nkrumah,Enrico Peiretti,Jay Chhablani,Michele Lanza,Mohammed Nasar Ibrahim,Asiya Jabeen,Khushboo Chandra,Sumit Randhir Singh,Niroj Kumar Sahoo,Oliver Beale,Filippo Tatti

doi:10.3390/diagnostics11050861

Abstract

Background: To map the choroidal vascularity index and compare two eyes in patients with unilateral central serous chorioretinopathy (CSCR). Methods: This was a retrospective, observational study performed in patients with unilateral CSCR. Choroidal thickness (CT) and Choroidal vascularity index (CVI) were measured and mapped in various zones according to the early treatment diabetic retinopathy (ETDRS) grid. Results: A total of 20 CSCR patients (20 study and 20 fellow eyes) were included in the study. Outer nasal region CT was seen to be significantly lower than central CT (p = 0.042) and inner nasal CT (p = 0.007); outer ring CT was significantly less than central (p = 0.04) and inner ring (p = 0.01) CT in CSCR eyes. On potting all the CVI values against the corresponding CT values, a positive correlation was seen in CSCR eyes (r = 0.54, p < 0.01), which was slightly weaker in fellow eyes (r = 0.3, p < 0.01) and a negative correlation was seen in healthy eyes (r = −0.262, p < 0.01). Conclusions: Correlation between CVI and CT was altered in CSCR eyes as compared to fellow and normal eyes with increasing CVI towards the center of the macula and superiorly in CSCR eyes.

Highlights

On potting all the Choroidal vascularity index (CVI) values against the corresponding Choroidal thickness (CT) values, a positive correlation was seen in central serous chorioretinopathy (CSCR) eyes (r = 0.54, p < 0.01), which was slightly weaker in fellow eyes (r = 0.3, p < 0.01) and a negative correlation was seen in healthy eyes (r = −0.262, p < 0.01)
The choroidal thickness was found to be significantly higher in all the sub-fields except inner inferior and outer superior sub-fields in CSCR eyes compared to fellow eyes and healthy normal controls
Acute CSCR is characterized by choroidal congestion which can be seen on optical coherence tomography (OCT) as an increased choroidal thickness [1,2,12]

Summary

Introduction

By altering the area of segmentation in enface OCTs and OCT angiographies (OCTA), information can be obtained comparable or superior to conventional ICG without the concern of any invasive procedure [4,5,6]. The uniqueness of these modalities lies in the ease of assessment of various quantifiable parameters such as thickness, volume and indices, which were limited in traditional dye angiograms. To map the choroidal vascularity index and compare two eyes in patients with unilateral central serous chorioretinopathy (CSCR).

Methods

Results

Discussion

Conclusion