Abstract
PurposeTo analyse morphologic features of the choroid in Non-pathological myopic eyes using spectral-domain (SD) optical coherence tomography (OCT).MethodsRetrospective analysis of enhanced depth SD-OCT images of Non-pathological myopic eyes in comparison with age-matched healthy controls was performed. Choroidal thickness (CT) and large choroidal vessel thickness (LCVT) were measured at the fovea, 750 µm nasally from fovea (N750) and 750 µm temporally (T750) from fovea. Medium choroidal vessel thickness (MCVT) was calculated by subtracting LCVT from CT. Choriocapillaris was encompassed by MCVT, given its reduced thickness. Linear regression analysis evaluated the relationship between age and axial with CT, LCVT and MCVT.ResultsThe study group comprised 42 eyes of 31 patients (mean age 46.13 ± 15.63; 15 females). Control group included 57 eyes of 34 patients (mean age of 42.3 ± 15.29; 24 females). Mean axial length in myopic eyes and control group was 26.57 ± 1.27 and 23.59 ± 0.99 mm respectively. Myopic eyes showed significant thinning of MCVT and CT at all locations (p < 0.0001) compared to controls, unlike LCVT (p > 0.05). With each decade, thinning of up to 37 µm in CT was noted along with thinning of LCVT (up to 22.6 µm) and MCVT (up to 25 µm). Each mm increase in axial length caused 38.2 µm thinning of choroid along with LCVT (<10 µm), however, MCVT showed more notable thinning (>30 µm).ConclusionSignificant thinning of MCVT was noted in non-pathological myopic eyes in comparison to healthy subjects. It appears that MCVT has stronger relationship with age and axial length.
Highlights
Myopia is a prevalent cause of vision impairment, the cause and exacerbating factors are not completely understood
Histological analysis has revealed choroidal thinning in myopia, reported to be between 11 and 13 μm of thickness lost for each decade of life, and 6–9 μm lost with each dioptre of myopia [1]
Study cohort Retrospective analysis of Enhanced depth imaging (EDI) SD-optical coherence tomography (OCT) scans was performed for eyes with non-pathological myopia and compared to age-matched healthy subjects
Summary
Myopia is a prevalent cause of vision impairment, the cause and exacerbating factors are not completely understood. Progressive choroidal thinning has been found to be Enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT) is an acquisition technique that places OCT images near the zero-delay line, so the roll-off of sensitivity does not compromise image registration. It provides better documentation of Alshareef et al Int J Retin Vitr (2017) 3:28 deeper structures such as the choroid and choroidal-scleral interface, contributing to better delineation between the layers of the choroid. The aim of the present investigation is to analyse individual layers in relation to choroidal thinning of non-pathological myopic eyes, comparing the findings with age-matched healthy controls EDI has confirmed the histopathological findings of choroidal thinning in myopes [1]; the interrelationship between choroidal layers and choroidal thinning has not been assessed.
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