Choroidal thickness of chronic central serous chorioretinopathy with spectral-domain optical coherence tomography

Abstract

[Objective] To observe the choroidal thickness of patients with chronic central serous chorioretinopathy (CSC) in affected eyes and unaffected fellow eyes,[Methods] Forty-five chronic CSC patients diagnosed by fundus pre-set lens,fundus fluorescein angiography (FFA) and indocyanine green angiography were enrolled in this study.The patients included 36 males and nine females,with a mean age of (46.18±8.20) years,with a mean duration of (16.34±7.23) months.Thirty-six patients were affected unilaterally and nine patients affected bilaterally.The patients were divided into affected eyes group (group A,51 eyes) and unaffected fellow eyes group (group B,39 eyes).Fifty age-,sex-and diopter-matched normal subjects (50 eyes) were enrolled in this study as control group (group C).Enhanced depth imaging (EDI) choroidal scans were obtained in all eyes by using spectral-domain optical coherence tomography.Subfoveal choroidal thickness (SFCT) and choroidal thickness at 3 mm nasal (NCT3mm),temporal (TCT3mm),superior (SCT3 m),inferior (ICT3 mm) to the fovea were measured.[Results] The mean SFCT of group A,B and C were (436.76 ± 87.01),(394.71± 61.63),(294.86 ± 75.30) μm respectively.The mean SFCT of group A and B were thicker than group C,the difference was significant among three groups (F=44.791,P＜0.001).There were difference between group A,B,C in NCT3mm,TCT3 m,SCT3mm and ICT3mm (F=15.816,22.823,15.147,11.527; P＜0.001).The mean SFCT in affected eyes of unilateral patients was (416.34 ±79.44) μm,which was thicker than that in unaffected fellow eyes (t=2.897,P=0.007).[Conclusion] Choroidal thickness increased significantly in affected eyes and unaffected fellow eyes in patients with chronic CSC. Key words: Retinal diseases/pathophysiology; Choroid diseases/pathophysiology; Tomography,optical coherence; Diagnostic imaging