Choroidal Melanoma With Ultrasound-Guided Episcleral Brachytherapy: Long-Term Results and Risk of Metastasis

Abstract

To elucidate the long-term outcomes in patients with choroidal melanoma who received episcleral brachytherapy with 125-I seeds; analyze cause-specific survival, metastasis-free survival and local control and establish the relationship between tumor size and metastases.From May 2007 to February 2013, 88 patients classified according to American Joint Committee on Cancer guidelines underwent ultrasound-guided episcleral brachytherapy with a total prescribed dose of 72.40 Gy to the apex.Among the included cases, 47.7% and 44.3% had a clinical tumor stage of T2 and T3, respectively. With a median follow-up of 84 (range 7-153) months, local control at 5 and 10 years was 100% and 95%, respectively. Among the 88 patients, 9 (10.2%) were enucleated after brachytherapy. Those with T1-T2 and T3-T4 disease had a 10-year cause-specific survival of 100% and 87.3%, respectively (P = 0.017). Metastasis-free survival at 5 and 10 years was 100% in those with T1-T2 disease and 92.1% and 83.1% in those with T3-T4, respectively (P = 0.016). Five patients had liver metastases, all of whom had T3-T4 disease.Ultrasound-guided episcleral brachytherapy with 125-I seeds yielded excellent local control for choroidal melanoma, with low complication rates and 90% eye preservation. Given the association between tumor stage and liver metastases, which remain the main cause of death, stricter control should be employed for T3-T4 tumors for the early detection and treatment of relapses.B. Quiles Hevia: None. J. Mataix: None. J. Guinot: None. V. De los Dolores: None. M. Pena: None. A. La Rosa: None. M. Tortajada: None. M. Santos: None. P. Santamaria: None. S. Canós: None. M. Chust: None. J. Mengual: None. Y. Murria: None. M. Perez: None. C. Pesudo: None. L. Arribas Alpuente: None.