Choroidal changes of macular edema with serous macular detachment in non-proliferative diabetic retinopathy patients

Abstract

[Objective] To observe the choroidal changes of diabetic macular edema (DME) with serous macular detachment (SMD) in non-proliferative diabetic retinopathy (NPDR) patients by optical coherence tomography (OCT),[Methods] Nine NPDR patients including DME with SMD in one eye (SMD group) and only DME in the other eye (DME group) were enrolled.These 18 eyes were also divided into PRP group (six eyes,received panretinal photocoagulation before) and non-PRP group (12 eyes).Spectral domain EDI (enhance depth imaging)-OCT and fundus photograph were performed in all the eyes.The subfoveal choroidal thickness was measured.The choroidal simulation area acquired by horizontal EDI-OCT scan through the center of the foves was calculated by Image Plus Pro 6.0 software.The difference between DME and SMD group was compared and analyzed with matched t test; the difference between PRP and non-PRP group was compared and analyzed with F test.[Results] In SMD group,spindle-like or dome-like low signal of detachment areas with intact external limiting membrane were found in the retinal detachment region,and the inner and outer segments (IS/OS) were separated from the retinal pigment epithelium (RPE)-Bruch membrane.Both subfoveal choroidal thickness and choroidal simulation area in SMD group were significant greater than those in DME group (t=2.306,2.306 ;P＜0.05).Choroidal simulation area in PRP group was larger than that in non-PRP group (F =5.227,P＜0.05).But there was no significant difference of subfoveal choroidal thickness between PRP and non-PRP group (F =3.276,P＞ 0.05).[Conclusion] EDI-OCT detects spindle-like or dome-like low signal areas in detachment region of SMD with DME in NPDR patients. Key words: Diabetic retinopathy/complications; Macular edema/etiology; Tomography, optical coherence; Diagnostic imaging