Choroidal changes by ocular coherence tomography in white dot syndrome

Abstract

PurposeTo evaluate the findings of optical coherence tomography (OCT) in the acute and convalescent stages in patients with white dot syndrome. Patients were followed up at our clinic for at least 6 months. Materials and methodsA consecutive case series of patients with white dot syndrome were enrolled in this study. Only patients with disease onset less than 1 week were included in this study. Slit-lamp biomicroscopy, indirect ophthalmoscopy, fluorescein angiography, indocyanine green angiography (ICGA), OCT, visual field test, and corrected decimal visual acuity test were performed on all patients. ResultsA total of eight eyes from eight patients were analyzed in this study, including cases with acute zonal occult outer retinopathy (AZOOR), punctate inner choroidopathy and AZOOR, multiple evanescent white dot syndrome, and multifocal choroiditis. In the acute stage, OCT demonstrated diffuse or segmental attenuation/loss of inner segment/outer segment (IS/OS) signal. Choroidal thickening with increased choroidal vascular porosity as compared with the fellow eyes was noted in all eyes. The ICGA showed hypofluorescence patches in the late phase. In the convalescent stage, complete or partial restoration of photoreceptor IS/OS was noted along with a partial or complete resolution of choroidal thickening and choroidal vascular porosity in OCT. The ICGA also demonstrated resolved choroidal hypofluorescence in the convalescent stage. ConclusionChoroidal thickening and increased choroidal vascular porosity in addition to disruption of photoreceptor IS/OS were characteristic OCT features of white dot syndrome. Recovery of vision was accompanied with restoration of OCT findings in both retina and choroid.