Choriocapillaris Perfusion after 8 Weeks of High-Speed Circuit Training in Older Healthy Adults

Abstract

Purpose The aim of this study was to examine the impact of an 8-week high-speed circuit resistance training program (HSCT) on choriocapillaris density (CCD) in healthy older adults. Methods Eighteen cognitively normal older adults were enrolled and randomly assigned to either the HSCT or the control group (CON). The HSCT group was comprised of 11 participants who trained three times a week for eight weeks, while the CON group consisted of 7 participants who did not engage in formal training. Optical coherence tomography angiography (OCTA) was employed to image both eyes of each subject at baseline and at the 8-week follow-up. The choriocapillaris density (CCD) of 2.5 mm in diameter centered on the fovea was measured. Results The average age of the HSCT group was 70.3 ± 5.7 years, which was not different from the CON group (average age: 71.6 ± 5.2 years, p = 0.62). There were no significant changes in CCD between baseline and the 8-week follow-up in either the HSCT or the CON group—specifically, the baseline CCD in the HSCT group was 63.3% ± 5% (Mean ± SD), which did not differ significantly from the 8-week follow-up after HSCT training (64.7% ± 4%, p = 0.19). Likewise, there was no significant difference in CCD between baseline and the 8-week follow-up in the CON group (63.3% ± 3% and 62.7% ± 5%, respectively, p = 0.66). Conclusion CCD appeared to remain stable after 8 weeks of HSCT in healthy older individuals, possibly due to autoregulation. Further research with extended training may be necessary to verify these findings.