Abstract

Abstract The recent introduction of olanzapine (Zyprexa) has provided another first-line antipsychotic treatment option in the pharmacologic treatment of psychiatric patients. Unlike clozapine which is restricted to use with refractory schizophrenia, olanzapine is labeled for the management of manifestations of psychotic disorders. This implies a much larger potential treatment population besides schizophrenia, and nurses should consider its use beyond patients with treatment-resistant schizophrenia. Matters of therapeutic dosing, titration, and maintenance dosing are remarkably simple with this compound. With the current availability of olanzapine, nurses will need to be familiar with the issues surrounding conversion from other antipsychotic agents to this new agent.

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