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Abstract
Chondrosarcomas (CSs) are rare malignant tumors composed of cells derived from the transformed chondrocytes. Only 2% of the total cases of CS are found at the skull base, thus representing a 0.1-0.2% prevalence. We present the case of a patient with CS at the middle cranial fossa who was admitted for surgery to the Burdenko National Medical Research Center of Neurosurgery. In addition, we engage in a review of the literature to discuss the current approaches to the diagnostics and surgery of CS and delve deep into its embryo- and oncogenesis.
Highlights
Chondrosarcomas (CSs) are rare malignant tumors composed of cells derived from the transformed chondrocytes
Chondrosarcomas (CSs) are rare malignant mesenchymal tumors comprising cells derived from the transformed chondrocytes
2% of all CSs are found at the skull base, accounting for a 0.1-0.2% prevalence [2,3]. They are characterized by slow growth and destruction of the basilar skull bones; these tumors belong to high-grade malignancies with rapid growth and early metastatic spread
Summary
Chondrosarcomas (CSs) are rare malignant mesenchymal tumors comprising cells derived from the transformed chondrocytes. 2% of all CSs are found at the skull base, accounting for a 0.1-0.2% prevalence [2,3] They are characterized by slow growth and destruction of the basilar skull bones; these tumors belong to high-grade malignancies with rapid growth and early metastatic spread. A compact, well-delineated lesion of the medial temporal area was found It had a hyperintense signal in T2 and a hypointense signal at T1 and showed no contrast uptake. G: a positive immunohistochemical reaction with an S100 protein antibody was determined in the tumor sample
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