Abstract
The concentration of chondroitin sulphate and hyaluronic acid in the synovial fluids obtained from 25 patients with rheumatoid arthritis and from 9 healthy donors was determined. There was no correlation between the concentrations of the acidic glycosaminoglycans and the grade of local articular changes, but there was a highly significant positive correlation between the concentrations of chondroitin sulphate and hyaluronic acid. This indicates a common origin for these acidic glycosaminoglycans, the synovial lining cells. Probably chondroitin sulphate is also released from the cartilage into the synovial cavity in rheumatoid joints, where there are also osteoarthrotic changes.
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