Abstract
1. (1) Chondroitin sulfate isomers in the tunica intima of human aorta at different grades of atherosclerosis were studied by using enzymatic digestion methods with chondroitinases and chondrosulfatases. 2. (2) The total amounts of chondroitin sulfates tended to decrease with advanced atherosclerosis, but there was no obvious change in the distribution of chondroitin sulfate isomers in relation to atherosclerosis. 3. (3) Chondroitin or undersulfated chondroitin sulfate as well as oversulfated chondroitin sulfate were found in the disaccharide subunits as minor components of aortic chondroitin sulfates.
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