Abstract
Chondrocyte Viability in Human Nasal Septum After Morselization
Highlights
Considerable debate continues amid contradictory findings on the ultimate fate of grafts after morselization, and on whether the cartilage remains viable, resorbs, or is replaced by scar tissue.[1,2,3,4,5,6,7] Previous studies use cell viability analysis methods that likely underestimate cell death and lack ability to visualize the distribution of nonviable cells
Rohit Garg, MD, MBA, Mohammad Shaikh, BS, Allen Foulad, BS, and Brian Wong, MD, PhD Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery (Drs Garg and Wong), The Beckman Laser Institute (Drs Garg and Wong and Mssrs Shaikh and Foulad), and Departments of Biomedical Engineering and Surgery (Dr Wong), University of California, Irvine
Some surgeons are hesitant to use crushed cartilage owing to its perceived clinical unpredictability
Summary
Considerable debate continues amid contradictory findings on the ultimate fate of grafts after morselization, and on whether the cartilage remains viable, resorbs, or is replaced by scar tissue.[1,2,3,4,5,6,7] Previous studies use cell viability analysis methods that likely underestimate cell death and lack ability to visualize the distribution of nonviable cells. We examined the distribution of live and dead chondrocytes in crushed cartilage and correlate the degree of morselization with viability and mechanical stability. The degree of cartilage crushing produced using a Cottle morselizer varies widely and is surgeon dependent.
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