Abstract
Objective: To evaluate the usefulness of the measurement of fasting serum levels of cholylglycine in patients with cirrhosis and to compare these with standard liver tests. Method: Serum levels of cholylglycine were measured by radioimmunoassay in 82 patients with cirrhosis who also underwent a complete clinical and laboratory evaluation. Results: Of the patients, 86.6% (68% with Child’s class A cirrhosis, 87% with B and 97% with C; (P = 0.015) had increased cholylglycine serum levels. There were many significant correlations between cholylglycine and other liver tests. We also found a significant association with several clinical parameters characteristic of advanced liver disease. The severity of cirrhosis also correlated with cholylglycine serum levels (P = 0.008). Bile acid levels were found to be the most sensitive of the liver tests studied. Conclusions: Raised cholylglycine serum levels are associated with liver dysfunction. Measurement of fasting cholylglycine levels could be useful as a marker of severity in the evaluation and follow-up of cirrhotic patients, and could be applied along with other commonly used liver tests. © Current Science Ltd.
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