Abstract
Biosensors are analytical devices being approachable for multiple analytes assay. Here, biosensors with intercepted acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) are presented as tool for assay of anticholinergic compounds such as pesticides, nerve agents and some natural toxins. Principle of assay is based on evaluation of cholinesterase activity and its pertinent decrease in presence of analyte. Nerve agents, pesticides, anticholinergic drugs useable for treatment of Alzheimer′s disease as well as myasthenia gravis and aflatoxins are enlisted as compounds simply analyzable by cholinesterase biosensors.
Highlights
Inhibition of two enzymes in body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) is a common toxicology pathway of many compounds
Pesticides, anticholinergic drugs useable for treatment of Alzheimers disease as well as myasthenia gravis and aflatoxins are enlisted as compounds analyzable by cholinesterase biosensors
Assay of typical anticholinergic compounds such as organophosphates, organophosphonates and carbamates by biosensors as well as biosensors principles and constructions are mentioned in the review
Summary
Inhibition of two enzymes in body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) is a common toxicology pathway of many compounds. Biosensors with intercepted acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) are presented as tool for assay of anticholinergic compounds such as pesticides, nerve agents and some natural toxins. Principle of assay is based on evaluation of cholinesterase activity and its pertinent decrease in presence of analyte. Pesticides, anticholinergic drugs useable for treatment of Alzheimers disease as well as myasthenia gravis and aflatoxins are enlisted as compounds analyzable by cholinesterase biosensors.
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