Abstract
Carbachol induced a dose-dependent accumulation of inositol monophosphates in the Wistar rat pineal gland. The relative potency of muscarinic antagonists (atropine > pirenzepine ⪢ gallamine) in blocking this response suggests the involvement of muscarinic M 1 receptors. Following bilateral superior cervical ganglionectomy, the carbachol-induced phosphoinositide response was similar to that seen in sham-operated controls, while adrenergic response was enhanced by 50%. The results indicate that the pineal has functional muscarinic receptors which are not affected by removal of the sympathetic innervation to the gland.
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