Cholinergic lesions of the medial septum impair where-which memory but not episodic memory in the rat

Abstract

Event Abstract Back to Event Cholinergic lesions of the medial septum impair where-which memory but not episodic memory in the rat Alexander Easton1*, Ann Fitchett1, Mark Baxter2 and Madeline Eacott1 1 Durham University, Department of Psychology, United Kingdom 2 Oxford University, United Kingdom Lesions of the fornix and hippocampus impair performance of an episodic memory task in rats that assesses memory for what happened where and on which occasion. The cholinergic basal forebrain projects to the hippocampus primarily from the medial septum, and the presented study examined performance of animals with immunotoxic lesions of the cholinergic cells of the medial septum on this task of episodic memory. The cholinergic lesioned animals were able to perform the episodic memory task and were no different from sham lesioned control animals. In contrast, on a sponteneous task that required the animals to remember which location had been filled on a particular occasion cholinergic lesioned animals were not above chance levels and were significantly worse than sham animals. Performance of the cholinergic lesioned animals was restored when returned to the episodic memory task. We discuss the result in terms of the contribution of the cholinergic system to hippocampal function in episodic memory, and in terms of the dissociation between episodic and non-episodic memory tasks in animals. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Easton A, Fitchett A, Baxter M and Eacott M (2009). Cholinergic lesions of the medial septum impair where-which memory but not episodic memory in the rat. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.138 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 09 Jun 2009; Published Online: 09 Jun 2009. * Correspondence: Alexander Easton, Durham University, Department of Psychology, Durham, United Kingdom, alexander.easton@durham.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Alexander Easton Ann Fitchett Mark Baxter Madeline Eacott Google Alexander Easton Ann Fitchett Mark Baxter Madeline Eacott Google Scholar Alexander Easton Ann Fitchett Mark Baxter Madeline Eacott PubMed Alexander Easton Ann Fitchett Mark Baxter Madeline Eacott Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.