Choline metabolism biomarkers predict the risk of metabolic unfitness among young men

Abstract

To test the hypothesis that plasma choline metabolism biomarkers, alone and together with genetic determinants of one carbon (1‐C) metabolism, predict metabolic unfitness associated with a lipid overload (i.e. obesity), a cross‐sectional analysis was conducted involving 249 Mexican American men with a median age of 22 y. Circulating concentrations of choline, betaine, folate, metabolic unfitness indicators (i.e. lipid panel and liver enzymes), and polymorphisms of 1‐C metabolizing genes (i.e. MTHFD1 G1958A) were assessed. Bivariate partial correlation tests and multivariate regression models were performed in data analysis. Plasma choline positively and plasma betaine negatively associated with body mass index (BMI) with lower plasma betaine observed in men whose BMI > 25.8 kg/m2 (cohort median). In age‐ and BMI‐adjusted regression models, plasma betaine associated positively with serum HDL‐cholesterol. Further, plasma betaine associated negatively with serum alanine aminotransferase (ALT) among men with serum folate < 14.5 ng/mL (cohort median) or among men with at least one copy of MTHFD1 1958A allele. In sum, these data demonstrate that choline metabolism markers predict the risk of metabolic unfitness and support the need to investigate the potential therapeutic benefits of choline/betaine on metabolic fitness.Grant Funding Source : NIH Grant #S06GM053933 and California Agriculture Research Initiative