Abstract
In the title inclusion compound, 2C24H40O5·C8H6N2, the unit cell contains two molecules of cholic acid (3α,7α,12α-trihydroxy-5β-cholan-24-oic acid) and one molecule of quinoxaline which implies disorder of the quinoxaline in the space group P21. The amphiphilic molecules of cholic acid assemble, in an antiparallel arrangement, via O—H⋯O hydrogen bonds, into typical corrugated host bilayers which are lipophilic on the outside and lipophobic on the inside. The host framework belongs to the so called α-trans subtype. The quinoxaline molecules are accommodated in lipophilic channels formed between neighboring bilayers with only van der Waals interactions between host and guest. There is a crystallographic twofold screw axis directed along an empty channel in the host framework; however, neighboring guests in any one channel are related by a unit-cell translation along the b axis. Thus, the overall structure is a 1:1 superposition of two such channels related by the crystallographic twofold screw axis.
Highlights
In the title inclusion compound, 2C24H40O5C8H6N2, the unit cell contains two molecules of cholic acid (3,7,12-trihydroxy-5-cholan-24-oic acid) and one molecule of quinoxaline which implies disorder of the quinoxaline in the space group
The amphiphilic molecules of cholic acid assemble, in an antiparallel arrangement, via O—H O hydrogen bonds, into typical corrugated host bilayers which are lipophilic on the outside and lipophobic on the inside
The quinoxaline molecules are accommodated in lipophilic channels formed between neighboring bilayers with only van der Waals interactions between host and guest
Summary
In the title inclusion compound, 2C24H40O5C8H6N2, the unit cell contains two molecules of cholic acid (3,7,12-trihydroxy-5-cholan-24-oic acid) and one molecule of quinoxaline which implies disorder of the quinoxaline in the space group. The amphiphilic molecules of cholic acid assemble, in an antiparallel arrangement, via O—H O hydrogen bonds, into typical corrugated host bilayers which are lipophilic on the outside and lipophobic on the inside. The quinoxaline molecules are accommodated in lipophilic channels formed between neighboring bilayers with only van der Waals interactions between host and guest. There is a crystallographic twofold screw axis directed along an empty channel in the host framework; neighboring guests in any one channel are related by a unit-cell translation along the b axis. The overall structure is a 1:1 superposition of two such channels related by the crystallographic twofold screw axis
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