Abstract

Although the inhibition of cholesteryl ester transfer protein (CETP) was met with great hope as a potential mechanism for treating dyslipidemia, recent data from the ILLUMINATE trial (Journal Watch Cardiology Nov 5 2007) demonstrating increased mortality in patients receiving the CETP inhibitor torcetrapib have raised concerns about the viability of this approach. In particular, blood pressure elevation associated with torcetrapib was thought to contribute to its toxicity. To explore whether BP …

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