Abstract
The influence of copper deficiency on the appearance of newly synthesized cholesterol in the plasma lipids of rats was examined following 3H mevalonate injection. At 181 days copper deficient rats exhibited a highly significant increase in plasma cholesterol concentration. Copper deficiency was associated with a greatly enhanced appearance of 3H in newly synthesized cholesterol and cholesteryl esters in the plasma lipids. A concomitant decrease in 3H incorporation into liver lipids was also observed. The results suggest that copper deficiency markedly influences the clearance of hepatic cholesterol to the plasma pool, and a highly significant correlation was observed between plasma copper concentrations and 3H incorporation into plasma cholesterol. The results are discussed in terms of a possible role for copper in lipoprotein metabolism, bile acid metabolism, and the uptake of cholesterol by extra-hepatic tissues.
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