Abstract
Incubation of rat aorta and intestine in vitro with dl-α-methylbenzyl-[1- 14C]-linoleamide (MBLA) results in the fairly selective formation of radioactive cholesterol esters and a radioactive complex between MBLA and free cholesterol. A much wider range of lipids is labelled after incubating liver in vitro with this drug. It is suggested that when MBLA is presented to the aorta and intestine in vitro as an intact molecule, these tissues can esterify cholesterol by a transamidation reaction between the drug and the sterol through an enzyme route that remains to be characterized. After administering the drug orally a wide range of lipds are labelled in plasma, liver and aorta: cholesterol esterification is not prominent.
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