Abstract
Free (unesterified) cholesterol is the single most abundant lipid species found in smooth muscle cell (SMC) plasma membrane and appears to have an important role in its membrane structure and physiology (1). In dietary atherosclerosis, the arterial SMC plasma membrane free cholesterol: phospholipid (C:PL) mole ration increased by 83% from 0.38 to 0.78 (1). Cholesterol enrichment in SMCs have been associated with the pathobiology of atherosclerosis, including marked changes in SMC transmembrane movements of cations and SMC proliferation (1-4).
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