Cholesterol Enrichment During Dietary Atherosclerosis Alters Smooth Muscle Plasma Membrane Width and Structure: Evidence for Reversal by the 1,4-Dihydropyridine Amlodipine

R Preston Mason,Thomas N Tulenko,Leo G Herbette

doi:10.1007/978-94-011-1725-8_21

Cholesterol Enrichment During Dietary Atherosclerosis Alters Smooth Muscle Plasma Membrane Width and Structure: Evidence for Reversal by the 1,4-Dihydropyridine Amlodipine

R Preston Mason, Thomas N Tulenko + Show 1 more

https://doi.org/10.1007/978-94-011-1725-8_21

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Publication Date: Jan 1, 1993

Citations: 2

Affiliation: University of Connecticut Health Center, Drexel University

#Smooth Muscle Cell #Smooth Muscle Cell Plasma Membrane + Show 8 more

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Abstract

Free (unesterified) cholesterol is the single most abundant lipid species found in smooth muscle cell (SMC) plasma membrane and appears to have an important role in its membrane structure and physiology (1). In dietary atherosclerosis, the arterial SMC plasma membrane free cholesterol: phospholipid (C:PL) mole ration increased by 83% from 0.38 to 0.78 (1). Cholesterol enrichment in SMCs have been associated with the pathobiology of atherosclerosis, including marked changes in SMC transmembrane movements of cations and SMC proliferation (1-4).

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