Abstract
Cholesterol is essential for the ability of cytotoxic Tcells to eliminate cancer cells. In this issue of Cancer Cell, Yan etal. reveal how intra-tumoral cholesterol deficiency contributes to Tcell exhaustion by inhibiting mTORC1 signaling. Moreover, they demonstrate that increasing cholesterol levels in chimeric antigen receptor (CAR)-T cells by blocking liver X receptor (LXR) leads to improved anti-tumor function.
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