Abstract
The purpose of this study was to examine the effect of single and repeated oral administration of the aqueous extract of Carum carvi L. fruits at a dose of (20 mg/kg) on lipid metabolism in normal and streptozotocin-induced diabetic rats (STZ). After a single oral administration, Carum carvi extract produced a significant decrease on triglycerides levels in normal rats ( p < 0.05). In STZ diabetic rats, cholesterol levels were decreased significantly 6 h after Carum carvi treatment ( p < 0.05). On the other hand, repeated oral administration of Carum carvi extract exhibited a significant hypotriglyceridemic and hypocholesterolemic activities in both normal ( p < 0.01 and <0.001 respectively) and STZ diabetic rats ( p < 0.001) 15 days after Carum carvi treatment. We conclude that the aqueous extract of Carum carvi (20 mg/kg) exhibits a potent lipid lowering activity in both normal and severe hyperglycemic rats after repeated oral administration of Carum carvi aqueous extract.
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