Abstract
AbstractCholesterol and phospholipids are major components of biological membranes. The role of cholesterol in membranes is not metabolic and is known to be a regulator of membrane fluidity which in turn regulates various biological phenomena. We have studied the nature of cholesterol and phospholipid interaction in artificial membranes using 13C NMR spectroscopy. This involved preparation of phospholipids specifically labeled with 13C in the ester carbonyl group. Though the chemical shift data did not provide very useful information the T1 and T2 measurements indicated that previously proposed H bonding between the ester carbonyl group and hydroxyl group of cholesterol seems unprobable.
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