Abstract
To the Editor: Simons et al.1 discussed the relationship between brain cholesterol metabolism and AD with particular focus on Aβ formation. Based on two retrospective clinical studies on a mixed dementia population (vascular dementia, sporadic Alzheimer dementia, secondary dementias) treated with statins, they expressed the hope that such a treatment may inhibit intracellular cholesterol formation, and as a consequence, reduce Aβ thus being beneficial for Alzheimer patients. This view was supported by investigations on both cell cultures of fetal hippocampal neurons and healthy adult guinea pigs both possessing intact cell membranes leading to reduced formation of Aβ under the treatment of a statin applied in a dose 200 to 400 times greater than used in humans. Cholesterol is an essential constituent of membranes and guarantees and stabilizes their function and structure. Membranes in Alzheimer brains were found to be severely damaged in their lipid …
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