Abstract
Sub-cellular fractionation tissue from rat hypothalamus and cerebral cortex in sucrose gradients indicated a concentration of cholecystokinin-like peptides in synaptosomal fractions. Lysis of synaptosomes yielded a vesicle rich fraction which was further enriched in cholecystokinin-like peptides, particularly the octapeptide (CCK-8). In vitro release experiments carried out using rat cerebral cortex tissue slices showed a calcium dependent release of cholecystokinin (primarily as CCK-8). The demonstration of a vesicular localization and calcium evoked release of cholecystokinin is consistent with a role for cholecystokinin as a neurotransmitter/neuromodulator in the CNS.
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