Abstract
Cholecystokinin Antagonists: Fluorinated 5-Hydroxy-5-Aryl-Pyrrol-2-Ones as Experimental Agents for Brain, Colon and Pancreatic Cancer
Highlights
In terms of cholecystokinin-physiology,[1] CCK-8 is the most common peptide hormone, which is extensively found throughout the gastrointestinal tract (GIT) and is widely distributed through the nervous system.[2]
Cholecystokinin acts as a neuromodulator as well as gut hormone and the cholecystokinin receptor has been extensively investigated as potential drug targets.[5]
Cholecystokinin does cause proliferation in colon- and pancreatic cancer cell lines and CCK-antagonists were studied as growth factor inhibitors in certain forms of cancer
Summary
In terms of cholecystokinin-physiology,[1] CCK-8 is the most common peptide hormone, which is extensively found throughout the gastrointestinal tract (GIT) and is widely distributed through the nervous system.[2]. Cholecystokinin does cause proliferation in colon- and pancreatic cancer cell lines and CCK-antagonists were studied as growth factor inhibitors in certain forms of cancer
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