Abstract

Women with an inherited mutation in BRCA1 or BRCA2 have a lifetime risk of breast cancer that ap- proaches 80% [...]

Highlights

  • The latter group of women includes those with a strong family history of breast cancer but no BRCA mutation 4, those with a mutation in CHEK2 5,6, those in the highest category of mammographic density 7, and those with a past history of lobular carcinoma in situ or atypical hyperplasia 8,9

  • In the United Kingdom, the Family History Study was undertaken to estimate how much life expectancy might reasonably be gained by an offer of annual mammography to women at moderate risk 10

  • Annual mammography was offered for 4 years to 6710 women with a family history of breast cancer who were younger than 50 years of age, but who were negative for both BRCA mutations

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Summary

Introduction

The latter group of women includes those with a strong family history of breast cancer but no BRCA mutation 4, those with a mutation in CHEK2 5,6, those in the highest category of mammographic density 7, and those with a past history of lobular carcinoma in situ or atypical hyperplasia 8,9. In the United Kingdom, the Family History Study was undertaken to estimate how much life expectancy might reasonably be gained by an offer of annual mammography to women at moderate risk 10. Annual mammography was offered for 4 years to 6710 women with a family history of breast cancer who were younger than 50 years of age, but who were negative for both BRCA mutations.

Results
Conclusion

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