Abstract
Background: In the recent years, there has been a significant rise in the invasive candida infections. Epidemiological studies have demonstrated a shift in the trend of Candida species being isolated and their susceptibility patterns. The present study was carried out to evaluate the single institution experience of the burden of invasive candidemia. Methods: This prospective study was carried out among 48 candida isolates from blood and urine samples among patients hospitalized in intensive care unit (ICU) for a period of two years. Gram staining, culture and anti-fungal susceptibility testing were carried out on all the samples. Results: Highest occurrence of candidemia was in the age group of 41-60 years with a 50% male predominance. The case fatality rate among the study participants was 54%. Type 2 diabetes mellitus was a significant risk factor, with 45.8% of the candidemia patients being diabetic and 72.7% of the diabetics who developed candidemia expired (p value 0.035). In this study, 23% were Candida albicans and 77% non albicans species. Candida tropicalis (n=24) was the most frequently isolated organism. Out of the patients who expired, 27% of the isolates were albicans species and 73% of the isolates were non albicans species (p value 0.177).
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