Abstract
The antibiotic chlortetracycline (CTC) and the non-steroidal anti-inflammatory drug- acetaminophen (ACE) are common drug residues in water environment because they can not be degraded completely in treatment industry. They could be potentially affect non-target aquatic organisms when they are input into an aquatic system. To investigate the impact of CTC and ACE on aquatic system, in this study, on day 1, 2 and 7 after Sinotaia quadrata exposed to either CTC (0, 0.1 and 5.0 mg L^(-1)) or ACE (0, 0.1 and 5.0 mg L^(-1)), six biochemical parameters were determined in the hepatopancreas, including the activities of monooxygenase (Mon) and glutathione-S-transferase (GST), the concentrations of hematopancrease-associated glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase(GPT) and the amount of excretory function-related creatinine(CREA) and urea nitrogen(UREA). After treatment with 5 mgL^(-1) of CTC for 7 days, the Mon activity (2.09-5.00 △A/30 min/mg) was higher than that of control group (0.29-1.74 △A/30 min/mg), however, the change of the remaining parameters were not detected. In group treated with 5 mgL^(-1) of ACE, the Mon activity (1.57-2.57 △A/30 min/mg) and the concentrations of GOT, GPT and UREA were significantly increased. These results suggest that the detoxification may be initiated when the both drug residues in aquatic environment were more than 5 mgL^(-1), and the ACE has deleterious effects on the aquatic organisms. Therefore, the risk of drug residues at water ecology will be an important environmental issue.
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