Abstract
SUMMARY. Chlorpropamide alcohol flushing (CPAF) has been suggested as a genetic marker for a type of non-insulin dependent diabetes mellitus characterized by a strong genetic disposition and a low frequency of retinopathy. This theory has not been supported by later investigations. Studies indicate that the most likely primary event in the CPAF phenomenon is an increased blood acetaldehyde level as a consequence of decreased acetaldehyde degradation. Probably the decreased elimination of acetaldehyde is elicited through an inhibitory effect of chlorpropamide on acetaldehyde dehydrogenase, the effect being most pronounced in subjects who have a genetically determined low activity of this enzyme. Key words: Diabetes, chlorpropamide, ethanol, acetaldehyde.
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